Oral Publications

Oral Bases

Beyond Use Date (BUD) studies are conducted in order to establish the conserved potency of an active after an adequate period of time and to guarantee the quality, purity and stability of compounded preparations. Accurate results ensure that a medication has maintained its compounded dosage form.

• Sulfamethoxazole/Trimethoprim 40/8 mg/mL
  St-Jean, I. Friciu M. Monfort, A. MacMahon, J. Forest, J-M. Walker, S. Leclair, G. (2021)
  Stability of Extemporaneously Compounded Suspensions of Trimethoprim and Sulfamethoxazole in Amber Plastic Bottles and Amber Plastic Syringes
  CJHP. Vol 74.No 4.
• Clozapine 25mg/mL and 50mg/mL
  Walker, S.E. Sachedina, H. Biachr, K. (2021).
  Stability of Compounded Clozapine 25mg/mL and 50mg/mL Suspensions in Plastic Bottles
  CJHP Vol 74 No. 3
• Nadolol 10mg/mL
  A. Walsh, B. Ziegler, K. Lingertat-Walsh, S. Law, S.E. Walker. (2021).
  Stability of Extemporaneously-compounded Nadolol 10-mg/mL Suspension in Oral Mix in Glass and Plastic Bottles and Plastic Syringes
  IJPC Vol 25 No. 2
• Acetazolamide 25mg/mL
  Gillium, C. Friciu, M. Abatzoglou, N. Leclair, G. (2020).
  Stability of Extemporaneously Prepared Acetazolamide Oral Suspensions at Two Temperatures
  JPPT Vol 25 No. 8
• Metronidazole 50mg/mL
  Jarouche M., Ibrahim M., Pearson J., Low M., Rowe J. (2020)
  Stability of Metronidazole Free-base Oral Suspensions Formulated with United States Pharmacopeia-grade Metronidazole Powder and Commercial Metronidazole Tablets
  IJPC Vol 24 No.1
• Dapsone 2mg/mL
  Alarie, H. Friciu, M. Leclair, G. (2018).
  Stability of Dapsone in Extemporaneously Compounded Oral Suspensions
  CJHP Vol 71 No.2
• Hydrocortisone 2mg/mL
  Manchanda, A. Laracy, M. Savji, T. Bogner, R. H. (2018).
  Stability of an Alcohol-free, Dye-free Hydrocortisone (2 mg/mL) Compounded Oral Suspension
  IJPC Vol 22 No.1
• Vancomycin 50mg/mL
  Smith, A. D. Rempel, G. Szeitz, A. Klassen, T. L. Ensom, M. H. H. (2017).
  Vancomycin 50 mg/mL Suspension in Oral Syrup: Stability in Plastic Bottles and Syringes at 2 Temperatures.
  CJHP Vol 70 No.3
• Gabapentin 100mg/mL
  Friciu, M. Roullin, V. G. Leclair, G. (2017).
  Stability of gabapentin in extemporaneously compounded oral suspensions.
  PLOS ONE 12(4) e0175208. doi: 10.1371/journal.pone.0175208
• Hydroxychloroquine sulfate 25mg/mL
  McHenry, A. R. Wempe, M. F. Rice, P. J. (2017).
  Stability of Extemporaneously Prepared Hydroxychloroquine Sulfate 25-mg/mL Suspensions in Plastic Bottles and Syringes.
  IJPC. Vol. 21, No 3.
• Tacrolimus 0.5mg/mL
  Friciu, M. Zaraa, S. Leclair, G. (2017).
  Stability of Extemporaneously Compounded Tacrolimus in Glass Bottles and Plastic Syringes.
  CJHP. Vol 70.No 1
• Enalapril maleate 1mg/mL
  Friciu, M. Zaraa, S. Leclair, G. (2016).
  Stability of Extemporaneously Prepared Enalapril Maleate in Glass Bottles and Plastic Syringes.
  CJHP. Vol 69.No 6
• Diazoxide 10mg/mL
  Friciu, M. Zaraa, S. Roullin, V. G. Leclair, G. (2016).
  Stability of Diazoxide in Extemporaneously Compounded Oral Suspensions.
  PLOS One 11(10) e0164577. doi:10.1371/journal.pone.0164577
• Amlodipine 1mg/mL
  Friciu, M. Zaraa, S. Leclair, G. (2016).
  Stability of Extemporaneously Compounded Amlodipine Besylate Oral Suspensions.
  CJHP. Vol 69.No 4.
• Piroxicam Suspension 10mg/mL - Veterinary Use
  Rase, T. M. Purohit, V. (2016).
  Stability of Extemporaneously Compounded Piroxicam 10mg/mL suspension with acetate buffer.
  Santa Clara County Veterinary Medical Association (SCCVMA) Annual Meeting 2016: Poster Abstract.
• Trimethoprim Suspension 10mg/mL
  Ensom, H. H. Mary, Decarie, D. (2016).
  Stability of Extemporaneously Compounded Trimethoprim in Glass and Plastic Bottles and Plastic Syringes.
  CJHP. Vol 69, No 2.
• Melatonin Suspension 2mg/mL
  Friciu, M. Savji, T. Zaraa, S. Leclair, G. (2016).
  Evaluation of stability of melatonin in extemporaneously compounded oral suspensions.
  JPPR. Vol 46, Issue 1.
• Dexamethasone (using tablets) Suspension 1mg/mL
  Ensom, H. H. Mary, Decarie, D. (2016).
  Dexamethasone 1 mg/mL Suspension Prepared from Crushed Tablets: Stability in Glass and Plastic Bottles and Plastic Syringes
  CJHP. Vol 69, No 1.
• Levetiracetam Suspension 50mg/mL
  Ensom, H. H. Mary, Decarie, D. (2015).
  Stability of Extemporaneously Compounded Levetiracetam in Glass and Plastic Bottles and Plastic Syringes.
  CJHP. Vol 68, No 4.
• Naproxen Suspension 25mg/mL
  Ensom, H. H. M., Decarie, D. Lingertat-Walsh, K. (2015).
  Stability of Extemporaneously Compounded Naproxen 25 mg/mL Suspension in Glass and Plastic Bottles and Plastic Syringes.
  CJHP. Vol 68, No 6.
• Prednisone Suspension 5mg/mL
  Friciu, M. Plourde, K. Leclair, G. Danopoulos, P. Savji, T. (2015).
  Stability of Prednisone in Oral Mix Suspending Vehicle.
  IJPC. Vol 19, No4
• Clobazam Suspension 1mg/mL
  Walsh Lingertat, K., Walsh, A., Ziegler, B., Walker, S. E., Law, S., Sales, P. (2014).
  Stability of extemporaneously compounded Clobazam 1mg/mL suspension.
  CSHP Professional Practice Conference.
• Clonidine Suspension 0.010mg/mL
  Ensom, H. H. Mary, Decarie, D. (2014).
  Stability of Extemporaneously Compounded Clonidine in Glass and Plastic Bottles and Plastic Syringes.
  CJHP. Vol 67, No 4.
• Dexamethasone Suspension 1mg/mL
  Ensom, H. H. Mary, Decarie, D. (2014).
  Stability of Extemporaneously Compounded Dexamethasone in Glass and Plastic Bottles and Plastic Syringes.
  CJHP. Vol 67, No 4.
• Pyridoxine Suspension 25mg/mL
  Ensom, H. H. Mary, Decarie, D. (2014).
  Stability of Extemporaneously Compounded Pyridoxine in Glass and Plastic Bottles and Plastic Syringes.
  CJHP. Vol 67, No 5.
• Spironolactone Suspension 5mg/mL
  BasuSarkar, A. Kandimalla, A. Dudley, R. (2013).
  Chemical Stability of Compounded Spironolactone Suspension in Proprietary Oral Mix Over a 90-day Period at Two Controlled Temperatures in Different Storage Containers.
  Int. J. Pharm. Sci. Rev. Res. Vol 23(1), No 14
• Premixed Excipient Blends
  Capsules have played a crucial role in drug delivery for pharmaceutical applications, although they tend to be difficult to prepare. To minimize the challenge of excipient selection and blend preparation, MEDISCA tests solubility and permeability, enhancing high level of efficiency of compounded capsules and ensuring dissolution of actives ingredients.
  Pinheiro, V. Danopoulos, P. Demirdjian, L. Nogueira, R. Dubois, F. (2013).
  In Vitro Evaluation of Extemporaneously Compounded Immediate-release Capsules with Premixed Excipients, Based on the Biopharmaceutical Classification System (BCS) of the drugs.
  IJPC. Vol. 17. No 5.